From the San Diego Airport:

Leave San Diego Airport and bear onto North Harbor Drive (towards downtown). Follow to West Grape Street and go to the I-5 South Ramp. Merge onto I-5 south and follow to 163 north. Take 163 north to I-15 north. Follow I-15 north to Carmel Mountain Road exit. Turn right at Carmel Mountain Road. Turn left at Rancho Carmel Road. Follow to the Avenue of Science and turn left. 15092 Avenue of Science will be on your left.

Total distance: 23.48 miles - 30 minutes

Courtyard by Marriott Rancho Bernardo
11611 Bernardo Plaza Court
San Diego, CA 92128
(858) 613-2000

Staybridge Suites by Holiday Inn
11855 Avenue of Industry
San Diego, CA 92128
(858) 487-0900

Doubletree Golf Resort
14455 Penasquitos Drive
San Diego, CA 92129
(858) 672-9100

Marriott Residence Inn
11002 Rancho Carmel Drive
San Diego, CA 92128
(858) 673-1900